The Turecki Lab

Principal Investigator: Gustavo Turecki, MD, PhD

Research Areas

  • Clinical phenotypes associated with suicidal behaviour
  • Molecular changes associated with early-life adversity, mood disorders and their comorbidities, and suicide
    • DNA modifications
    • Histone modifications
    • Noncoding RNAs (ncRNAs; lncRNAs, miRNAs, etc.)
    • Polyamines
    • Inflammatory markers
  • Biomarkers of MDD treatment response or relapse and suicidal events
    • Molecular biomarkers
    • Neural correlates
  • Gene expression studies

Suicide brain banking

Contributions to the Suicide Section of the Douglas-Bell Canada Brain Bank

Key publications

  • Lutz, P.E., et al. Association of a History of Child Abuse With Impaired Myelination in the Anterior Cingulate Cortex: Convergent Epigenetic, Transcriptional, and Morphological Evidence. The American journal of psychiatry 174, 1185-1194 (2017). PMID: 28750583.
  • Lopez, J.P., et al. MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes. Nature communications 8, 15497 (2017). PMID: 28530238.
  • Gross, J.A., et al. Gene-body 5-hydroxymethylation is associated with gene expression changes in the prefrontal cortex of depressed individuals. Translational psychiatry 7, e1119 (2017). PMID: 28485726.
  • Turecki G, Brent DA. Suicide and suicidal behaviour. Lancet 2016;387(10024):1227-1239. PMID:26385066.
  • Cruceanu C, et al. Transcriptome Sequencing of the Anterior Cingulate in Bipolar Disorder: Dysregulation of G Protein-Coupled Receptors. Am J Psychiatry 2015;172(11):1131-40. PMID: 26238605.
  • Nagy C, et al. Astrocytic abnormalities and global DNA methylation patterns in depression and suicide. Molecular psychiatry 2015;20(3):320-328. PMID:24662927.
  • Turecki G. The molecular bases of the suicidal brain. Nature reviews. Neuroscience 2014;15(12):802-816. PMID:25354482.
  • Lopez JP, et al. miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment. Nat Med 2014;20(7):764-8. PMID: 24908571.
  • Lopez JP, et al. Epigenetic regulation of BDNF expression according to antidepressant response. Mol Psychiatry 2013;18(4):398-9. PMID: 22547115.
  • Labonte B, et al. Genome-wide epigenetic regulation by early-life trauma. Arch Gen Psychiatry 2012;69(7):722-31. PMID: 22752237.
  • Turecki G, et al. The neurodevelopmental origins of suicidal behavior. Trends in neurosciences 2012;35(1):14-23. PMID:22177979.
  • Mamdani F, et al. Gene expression biomarkers of response to citalopram treatment in major depressive disorder. Transl Psychiatry 2011;1:e13. PMID: 22832429.
  • McGowan PO, et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 2009;12(3):342-8. PMID: 19234457.
  • Ernst C, et al. Alternative splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completers. Archives of general psychiatry 2009;66(1):22-32. PMID:19124685.
  • McGirr A, et al. Familial aggregation of suicide explained by cluster B traits: a three-group family study of suicide controlling for major depressive disorder. The American journal of psychiatry 2009;166(10):1124-1134. PMID:19755577.
  • Brezo J, et al. Predicting suicide attempts in young adults with histories of childhood abuse. The British journal of psychiatry : the journal of mental science 2008;193(2):134-139. PMID:18669998.
  • Sequeira A, et al. Implication of SSAT by gene expression and genetic variation in suicide and major depression. Archives of general psychiatry 2006;63(1):35-48.
  • Dumais A, et al. Risk factors for suicide completion in major depression: a case-control study of impulsive and aggressive behaviors in men. The American journal of psychiatry 2005;162(11):2116-2124. PMID:16263852.

Full publication list: Search G Turecki on PubMed

Funding Sources

brain-canada

Canadian Institutes of Health Research

frqs

nih

 

Current lab members

Daniel Almeida (PhD student)

Zahia Aouabed, MSc (Research associate – Bioinformatics)

Amanda Brown (MSc student)

Sarah Barnett-Burns (PhD student)

Gary Gang Chen, PhD (Technical operations manager)

Laura Fiori, PhD (Research associate)

Chelsey Ju (MSc student)

Elena Leonova-Erko (Biorepository coordinator)

Rixing Lin (MSc student)

Malosree Maitra (PhD student)

Corina Nagy, PhD (Project manager)

Kathryn Vaillancourt (PhD student)

Jennie Yang, MSc (Cell culture specialist)

Volodymyr Yerko, PhD (Lab manager)

View Alumni – Past Turecki Lab Members