Corina Nagy, PhD

Researcher, Douglas Research Centre

Assistant Professor, Department of Psychiatry, McGill University

Member, Quebec Network for Suicide, Mood Disorders, and Related Disorders (RQSHA)


Links

Profile

Corina Nagy, PhD, joined the Douglas Institute and the McGill Group for Suicide Studies in 2020. As an early career investigator, she is looking to push the limits of modern technology and explore the brain at an unprecedented resolution, examining the contribution of each brain cell to the pathological state with a focus on major depression.

Different research themes to be explored in her laboratory are:

  • Cell-specific underpinnings of sexual dimorphism in depression
  • Extracellular vesicle mediation of brain communication and plasticity
  • Cell-specific response to pharmacological treatment in depression

Key Publications:

For a full list of publications: https://www.ncbi.nlm.nih.gov/myncbi/1vweVHyOonHQv/bibliography/public/

  1. Bahrami M, Maitra M, Nagy C, Turecki G, Rabiee HR, Li Y. Deep feature extraction of single-cell transcriptomes by generative adversarial network. Bioinformatics. 2021 Jun 16;37(10):1345-1351. doi: 10.1093/bioinformatics/btaa976. PubMed PMID: 33226074.
  2. Maitra M, Nagy C, Chawla A, Wang YC, Nascimento C, Suderman M, Théroux JF, Mechawar N, Ragoussis J, Turecki G. Extraction of nuclei from archived postmortem tissues for single-nucleus sequencing applications. Nat Protoc. 2021 Jun;16(6):2788-2801. doi: 10.1038/s41596-021-00514-4. Epub 2021 May 10. Review. PubMed PMID: 33972803.
  3. Matosin N, Arloth J, Martinelli S, Czamara D, Maitra M, Halldorsdottir T, Cruceanu C, Kaul D, Gassen N, Hafner K, Müller NS, Worf K, Rehawi G, Nagy C, Scarr E, Tao R, Jaffe AE, Arzberger T, Falkai P, Kleinmann JE, Weinberger DR, Mechawar N, Schmitt A, Dean B, Turecki G, Hyde TM, Binder EB. Genotype and age influence cortical-FKBP5 at multiple regulatory and single-cell-type levels in severe psychiatric disorders. bioRxiv. 2021.
  4. Vaillancourt K, Yang J, Chen GG, Yerko V, Théroux JF, Aouabed Z, Lopez A, Thibeault KC, Calipari ES, Labonté B, Mechawar N, Ernst C, Nagy C, Forné T, Nestler EJ, Mash DC, Turecki G. Cocaine-related DNA methylation in caudate neurons alters 3D chromatin structure of the IRXA gene cluster. Mol Psychiatry. 2020 Oct 12;. doi: 10.1038/s41380-020-00909-x. [Epub ahead of print] PubMed PMID: 33046833; PubMed Central PMCID: PMC8039060.
  5. Nagy C, Maitra M, Tanti A, Suderman M, Théroux JF, Davoli MA, Perlman K, Yerko V, Wang YC, Tripathy SJ, Pavlidis P, Mechawar N, Ragoussis J, Turecki G. Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons. Nat Neurosci. 2020 Jun;23(6):771-781. doi: 10.1038/s41593-020-0621-y. Epub 2020 Apr 27. PubMed PMID: 32341540.
  6. Jessa S, Blanchet-Cohen A, Krug B, Vladoiu M, Coutelier M, Faury D, Poreau B, De Jay N, Hébert S, Monlong J, Farmer WT, Donovan LK, Hu Y, McConechy MK, Cavalli FMG, Mikael LG, Ellezam B, Richer M, Allaire A, Weil AG, Atkinson J, Farmer JP, Dudley RWR, Larouche V, Crevier L, Albrecht S, Filbin MG, Sartelet H, Lutz PE, Nagy C, Turecki G, Costantino S, Dirks PB, Murai KK, Bourque G, Ragoussis J, Garzia L, Taylor MD, Jabado N, Kleinman CL. Stalled developmental programs at the root of pediatric brain tumors. Nat Genet. 2019 Dec;51(12):1702-1713. doi: 10.1038/s41588-019-0531-7. Epub 2019 Nov 25. PubMed PMID: 31768071; PubMed Central PMCID: PMC6885128.
  7. Saeedi S, Israel S, Nagy C, Turecki G. The emerging role of exosomes in mental disorders. Transl Psychiatry. 2019 Mar 28;9(1):122. doi: 10.1038/s41398-019-0459-9. Review. PubMed PMID: 30923321; PubMed Central PMCID: PMC6438960.
  8. Maitra M, Nagy C, Turecki G. Sequencing the human brain at single-cell resolution. Current Behavioral Neuroscience Reports. 2019; 6(4):197-208.
  9. Nagy C, Vaillancourt K, Turecki G. A role for activity-dependent epigenetics in the development and treatment of major depressive disorder. Genes Brain Behav. 2018 Mar;17(3):e12446. doi: 10.1111/gbb.12446. Epub 2018 Jan 9. Review. PubMed PMID: 29251832.
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